GABA is the main inhibitory neurotransmitter and is abundant throughout the regions of the brain. It is also sought to play an important governing role in memory. Initial findings suggested that GABA agonists impair memory retention and consolidation and GABA inhibitors such as receptor antagonists and channel blockers enhance the same. These findings indicated inhibitory role of GABA on memory functions and portrayed GABA inhibitors to be possibly useful in memory deficit. On the contrary, studies also exhibited that the same GABA inhibitors produced amnesia when given in certain experimental condition. The explanations may be concealed in minute aspects such as difference in routes, doses and timings of the administration of agents manipulating the GABA level and location as well as density of receptor-subtypes in regions across the brain. There is a constant debate about what exact impact of alteration in GABAergic transmission is laid on the memory function. Extensive experimental research is required to establish the delicate concepts regarding GABA’s role play in memory and design new therapeutic strategies on the basis of the new knowledge to tackle conditions of memory deficits.
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